Bezafibrate
Title: Bezafibrate
CAS Registry Number: 41859-67-0
CAS Name: 2-[4-[2-[(4-Chlorobenzoyl)amino]ethyl]phenoxy]-2-methylpropanoic acid
Additional Names: 2-[p-[2-(p-chlorobenzamido)ethyl]phenoxy]-2-methylpropionic acid; a-[4-(4-chlorobenzoylaminoethyl)phenoxy]isobutyric acid
Manufacturers' Codes: BM-15075
Trademarks: Befizal (Oberval); Bezalip (Boehringer, Mann.); Bezatol (Kissei); Cedur (Boehringer, Mann.); Difaterol (Andreu)
Molecular Formula: C19H20ClNO4
Molecular Weight: 361.82
Percent Composition: C 63.07%, H 5.57%, Cl 9.80%, N 3.87%, O 17.69%
Literature References: Prepn: E. Witte et al., DE 2149070; eidem, US 3781328 (both 1973 to Boehringer, Mann.). Pharmacology: R. Zimmerman et al., Atherosclerosis 29, 477 (1978). Clinical studies: A. G. Olsson, P. D. Lang, ibid. 31, 421, 429 (1978); P. Wahl et al., Dtsch. Med. Wochenschr. 103, 1233 (1978). Review of pharmacodynamics and therapeutic use: J. P. Monk, P. A. Todd, Drugs 33, 539-576 (1987).
Properties: Crystals from acetone, mp 186°.
Melting point: mp 186°
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Fibrates.

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