Bucladesine
Title: Bucladesine
CAS Registry Number: 362-74-3
CAS Name: N-(1-Oxobutyl)adenosine cyclic 3¢,5¢-(hydrogen phosphate) 2¢-butanoate
Additional Names: N-(9-b-D-ribofuranosyl-9H-purin-6-yl)butyramide cyclic 3¢,5¢-(hydrogen phosphate) 2¢-butyrate; N6,2¢-O-dibutyryladenosine 3¢,5¢-cyclic monophosphate; N6,2¢-O-dibutyryl cAMP; DBcAMP
Molecular Formula: C18H24N5O8P
Molecular Weight: 469.39
Percent Composition: C 46.06%, H 5.15%, N 14.92%, O 27.27%, P 6.60%
Literature References: Vasodilating cyclic nucleotide derivative which can permeate the cell membrane. Mimics the action of endogenous cyclic AMP, q.v. Prepn: Th. Posternak et al., Biochim. Biophys. Acta 65, 558 (1962); O. Nagase et al., JP Kokai 76 113896, C.A. 86, 140409r (1977); T. Hirayama et al., JP Kokai 77 39698; JP 77 39699, C.A. 87, 136330m-136331n (1977) (1976, 1977, 1977 all to Daiichi Seiyaku). Pharmacology: H. S. White et al., Eur. J. Pharmacol. 57, 107 (1979); J. D. Johnson et al., ibid. 91, 343 (1983); N. Bondar et al., J. Physiol. 355, 33 (1984). Clinical trial in congestive heart failure: S. Matsui et al., Am. J. Cardiol. 51, 1364 (1983); after cardiopulmonary bypass surgery: T. Yoshitake et al., Prog. Clin. Biol. Res. 111, 211 (1983).
 
Derivative Type: Sodium salt
CAS Registry Number: 16980-89-5
Manufacturers' Codes: DC-2797
Trademarks: Actosin (Daiichi Seiyaku)
Molecular Formula: C18H23N5NaO8P
Molecular Weight: 491.37
Percent Composition: C 44.00%, H 4.72%, N 14.25%, Na 4.68%, O 26.05%, P 6.30%
 
Derivative Type: Barium salt
CAS Registry Number: 18837-96-2
Molecular Formula: C36H46BaN10O16P2
Molecular Weight: 1074.08
Percent Composition: C 40.26%, H 4.32%, Ba 12.79%, N 13.04%, O 23.83%, P 5.77%
Properties: uv max (ethanol-0.5M ammonium acetate, 5:2) 270 nm.
Absorption maximum: uv max (ethanol-0.5M ammonium acetate, 5:2) 270 nm
 
Therap-Cat: Cardiotonic.
Keywords: Cardiotonic.

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