Bufexamac
Title: Bufexamac
CAS Registry Number: 2438-72-4
CAS Name: 4-Butoxy-N-hydroxybenzeneacetamide
Additional Names: 2-(p-butoxyphenyl)acetohydroxamic acid; 2-[p-(butyloxy)phenyl]acetohydroxamic acid
Manufacturers' Codes: CP-1044-J3
Trademarks: Droxarol (Pharmos); Droxaryl (Continental Pharma); Feximac (Nicholas); Malipuran (Heumann); Mofenar (C.E.P.A.); Norfemac (HMR); Parfenac (Lederle); Parfenal (Cyanamid)
Molecular Formula: C12H17NO3
Molecular Weight: 223.27
Percent Composition: C 64.55%, H 7.67%, N 6.27%, O 21.50%
Literature References: Synthesis: N. P. Buu-Hoï et al., Compt. Rend. 261, 2259 (1965); eidem, BE 661226; eidem, US 3479396 (1965, 1969 to Madan). Pharmacology and toxicology: Lambelin et al., Med. Pharmacol. Exp. 15, 545 (1966).
Properties: Needles from acetone, mp 153-155°. Practically insol in water. LD50 orally in mice, rats: >8, >4 g/kg (Lambelin).
Melting point: mp 153-155°
Toxicity data: LD50 orally in mice, rats: >8, >4 g/kg (Lambelin)
Therap-Cat: Anti-inflammatory, analgesic, antipyretic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives; Antipyretic.

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