Title: Carphenazine
CAS Registry Number: 2622-30-2
CAS Name: 1-[10-[3-[4-(2-Hydroxyethyl)-1-piperazinyl]propyl]-10H-phenothiazin-2-yl]-1-propanone
Additional Names: 10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]-3-propionylphenothiazine; 2-propionyl-10-[g-(N¢-b-hydroxyethylpiperazino)propyl]phenothiazine
Trademarks: Proketazine (Wyeth)
Molecular Formula: C24H31N3O2S
Molecular Weight: 425.59
Percent Composition: C 67.73%, H 7.34%, N 9.87%, O 7.52%, S 7.53%
Literature References: Prepn: M. H. Sherlock, N. Sperber, US 2985654 (1961 to Schering); R. F. Tislow et al., US 3023146 (1962 to Am. Home Products).
Derivative Type: Dimaleate
CAS Registry Number: 2975-34-0
Molecular Formula: C24H31N3O2S.2C4H4O4
Molecular Weight: 657.73
Percent Composition: C 58.43%, H 5.98%, N 6.39%, O 24.33%, S 4.88%
Properties: Yellow crystals from isopropanol, mp 175-177° (Tislow). Also reported as crystals from methanol, mp 165-167° (Sherlock, Sperber).
Melting point: mp 175-177° (Tislow); mp 165-167° (Sherlock, Sperber)
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Phenothiazines.

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