Chlorpyrifos
Title: Chlorpyrifos
CAS Registry Number: 2921-88-2
CAS Name: Phosphorothioic acid O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester
Additional Names: O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate; chlorpyrifos-ethyl
Manufacturers' Codes: Dowco 179; ENT-27311
Trademarks: Affront (Wellmark); Dursban (Dow AgroSci.); Empire (Dow AgroSci.); Lock-On (Dow AgroSci.); Lorsban (Dow AgroSci.); Pyrinex (Makhteshim-Agan)
Molecular Formula: C9H11Cl3NO3PS
Molecular Weight: 350.59
Percent Composition: C 30.83%, H 3.16%, Cl 30.34%, N 4.00%, O 13.69%, P 8.83%, S 9.15%
Literature References: Prepn: R. H. Rigterink, FR 1360901; idem, US 3244586 (1964, 1966 both to Dow); R. H. Rigterink, E. E. Kenaga, J. Agric. Food Chem. 14, 394 (1966). Activity: E. E. Kenaga et al., J. Econ. Entomol. 58, 1043 (1965). Metabolism: G. N. Smith et al., J. Agric. Food Chem. 15, 132 (1967); W. H. Gutenmann et al., ibid. 16, 45 (1968). Toxicity study: Schafer, Toxicol. Appl. Pharmacol. 21, 315 (1972). Review of environmental fate: K. D. Racke, Rev. Environ. Contam. Toxicol. 131, 1-154 (1993); of toxicology and human exposure: Toxicological Profile for Chlorpyrifos (PB98-103088, 1997) 217 pp.
Properties: White granular crystals, mp 41-42°. Vapor pressure at 25°: 1.87 ´ 10-5 mm Hg. Soly at 25°: water 2 ppm; isooctane 79% w/w; methanol 43% w/w. Soly (g/100g): acetone 650, benzene 790, carbon disulfide 590, carbon tetrachloride 310, chloroform 630, diethyl ether 510, ethanol 63, ethyl acetate >200, isooctane 79, kerosene 60, methanol 45, methylene chloride 400, propylene glycol 4, toluene 150, 1,1,1-trichloroethane 400, triethylene glycol 5, xylene 400. Readily sol in other org solvents. uv max: 208, 230, 290 nm. LD50 orally in rats: 145 mg/kg (Schafer).
Melting point: mp 41-42°
Absorption maximum: uv max: 208, 230, 290 nm
Toxicity data: LD50 orally in rats: 145 mg/kg (Schafer)
 
Derivative Type: O,O-Dimethyl analog
CAS Registry Number: 5598-13-0
Additional Names: Chlorpyrifos-methyl
Manufacturers' Codes: Dowco 214; ENT-27520
Trademarks: Reldan (Dow AgroSci.)
Molecular Formula: C7H7Cl3NO3PS
Molecular Weight: 322.53
Percent Composition: C 26.07%, H 2.19%, Cl 32.98%, N 4.34%, O 14.88%, P 9.60%, S 9.94%
Properties: Crystals, mp 45.5-46.5°. Vapor pressure at 25°: 4.22 ´ 10-5 mm Hg. Soly in water at 25°: 5 mg/l.
Melting point: mp 45.5-46.5°
 
CAUTION: Potential symptoms of overexposure are wheezing, laryngeal spasms, salivation; bluish lips and skin; miosis, blurred vision; nausea, vomiting, abdominal cramps, diarrhea. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 70.
Use: Insecticide; acaricide.
Therap-Cat-Vet: Ectoparasiticide.

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