Ciprofloxacin
Title: Ciprofloxacin
CAS Registry Number: 85721-33-1
CAS Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
Manufacturers' Codes: Bay q 3939
Molecular Formula: C17H18FN3O3
Molecular Weight: 331.34
Percent Composition: C 61.62%, H 5.48%, F 5.73%, N 12.68%, O 14.49%
Literature References: Fluorinated quinolone antibacterial. Prepn: K. Grohe et al., DE 3142854; eidem, US 4670444 (1983, 1987 both to Bayer AG); K. Grohe, H. Heitzer, Ann. 1987, 29. Antibacterial spectrum in vitro: B. Watt, F. V. Brown, J. Antimicrob. Chemother. 17, 605 (1986); C. M. Bassey et al., ibid. 623. HPLC determn in biological fluids: W. Gau et al., J. Liq. Chromatogr. 8, 485 (1985). Pharmacokinetics: G. Hoffken et al., Antimicrob. Agents Chemother. 27, 375 (1985). Clinical trials: C. A. Ramirez et al., ibid. 28, 128 (1985); B. E. Scully et al., Lancet 1, 819 (1986). Symposia on antibacterial spectrum and clinical use: Am. J. Med. 82, Suppl. 4A, 1-404 (1987); J. Antimicrob. Chemother. 26, Suppl. F, 3-193 (1990). Review of clinical safety and efficacy in children: R. Kubin, Infection 21, 413-421 (1993).
Properties: Dec 255-257°.
 
Derivative Type: Monohydrochloride monohydrate
CAS Registry Number: 86393-32-0
Manufacturers' Codes: Bay o 9867
Trademarks: Baycip (Bayer); Ciflox (Bayer); Ciloxan (Alcon); Cipro (Bayer); Ciprobay (Bayer); Ciproxan (Bayer); Ciproxin (Bayer); Flociprin (IBI); Septicide (Bago); Uniflox (Bayer); Velmonit (Esteve)
Molecular Formula: C17H18FN3O3.HCl.H2O
Molecular Weight: 385.82
Percent Composition: C 52.92%, H 5.49%, F 4.92%, N 10.89%, O 16.59%, Cl 9.19%
Properties: Light yellow crystalline powder. mp 318-320°.
Melting point: mp 318-320°
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Quinolones and Analogs.

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