Clobetasol
Title: Clobetasol
CAS Registry Number: 25122-41-2
CAS Name: (11b,16b)-21-Chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Molecular Formula: C22H28ClFO4
Molecular Weight: 410.91
Percent Composition: C 64.30%, H 6.87%, Cl 8.63%, F 4.62%, O 15.57%
Literature References: Topical corticosteroid. Prepn: Elks et al., DE 1902340; eidem, US 3721687 (1969, 1973 both to Glaxo). Review of pharmacology and clinical efficacy in skin disorders: E. A. Olsen, R. C. Cornell, J. Am. Acad. Dermatol. 15, 246-255 (1986).
 
Derivative Type: 17-Propionate
CAS Registry Number: 25122-46-7
Manufacturers' Codes: GR-2/925
Trademarks: Clobesol (GSK); Dermovate (GSK); Olux (Connetics); Psorex (GSK); Temovate (GSK)
Molecular Formula: C25H32ClFO5
Molecular Weight: 466.97
Percent Composition: C 64.30%, H 6.91%, Cl 7.59%, F 4.07%, O 17.13%
Properties: White or almost white colorless, crystalline powder, mp 195.5-197°. [a]D +103.8° (c = 1.04 in dioxane). uv max (ethanol): 237 nm (e 15000). Insol in water.
Melting point: mp 195.5-197°
Optical Rotation: [a]D +103.8° (c = 1.04 in dioxane)
Absorption maximum: uv max (ethanol): 237 nm (e 15000)
 
Therap-Cat: Glucocorticoid; anti-inflammatory.
Keywords: Glucocorticoid.

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