Clobetasone
Title: Clobetasone
CAS Registry Number: 54063-32-0
CAS Name: (16b)-21-Chloro-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,11,20-trione
Additional Names: 21-chloro-11-dehydrobetamethasone
Molecular Formula: C22H26ClFO4
Molecular Weight: 408.89
Percent Composition: C 64.62%, H 6.41%, Cl 8.67%, F 4.65%, O 15.65%
Literature References: Prepn: Elks et al., DE 1902340; eidem, US 3721687 (1969, l973, both to Glaxo). Activity: Munro, Wilson, Br. Med. J. 3, 626 (1975). Radioimmunoassay: W. A. Webb, R. V. Brooks, Acta Endocrinol. Suppl. 212, 203 (1977). Toxicology: J. Tamura et al., J. Toxicol. Sci. 5, 45, 177 (1980). Comparative clinical studies: A. Lassus, Curr. Med. Res. Opin. 6, 165 (1979); T. Fredriksson, K. Nordin, ibid. 322. Clinical evaluation of ophthalmic form: D. Lloyd-Jones et al., Br. J. Ophthalmol. 65, 641 (1981); L. A. Eilon, S. R. Walker, ibid. 644; K. R. Wilhelmus et al., ibid. 699.
 
Derivative Type: 17-Butyrate
CAS Registry Number: 25122-57-0
Manufacturers' Codes: GR-2/1214
Trademarks: Emovate (GSK); Eumovate (GSK)
Molecular Formula: C26H32ClFO5
Molecular Weight: 478.98
Percent Composition: C 65.20%, H 6.73%, Cl 7.40%, F 3.97%, O 16.70%
Properties: Crystals from methanol, mp 90-100°.
Melting point: mp 90-100°
 
Therap-Cat: Glucocorticoid; anti-inflammatory.
Keywords: Glucocorticoid.

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