Clocortolone
Title: Clocortolone
CAS Registry Number: 4828-27-7
CAS Name: (6a,11b,16a)-9-Chloro-6-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Additional Names: 9-chloro-6a-fluoro-16a-methyl-1,4-pregnadiene-11b,21-diol-3,20-dione
Molecular Formula: C22H28ClFO4
Molecular Weight: 410.91
Percent Composition: C 64.30%, H 6.87%, Cl 8.63%, F 4.62%, O 15.57%
Literature References: Prepn: NL 6412708; E. K. Kaspar, R. Philippson, DE 2011559; eidem, US 3729495 (1965, 1971, 1973 all to Schering AG). Clinical trials: Wortmann, Wien. Med. Wochenschr. 122, 701 (1972); Baumann, Praxis 61, 536 (1972).
Properties: Crystals from methanol-methylene chloride, mp 254° (dec).
Melting point: mp 254° (dec)
 
Derivative Type: 21-Acetate
CAS Registry Number: 4258-85-9
Manufacturers' Codes: SH-818
Molecular Formula: C24H30ClFO5
Molecular Weight: 452.94
Percent Composition: C 63.64%, H 6.68%, Cl 7.83%, F 4.19%, O 17.66%
Properties: Crystals from methanol-methylene chloride, mp 252° (dec).
Melting point: mp 252° (dec)
 
Derivative Type: 21-Pivalate
CAS Registry Number: 34097-16-0
Manufacturers' Codes: CL-68; SH-863
Trademarks: Cloderm (Ortho); Purantix (Wander)
Molecular Formula: C27H36ClFO5
Molecular Weight: 495.02
Percent Composition: C 65.51%, H 7.33%, Cl 7.16%, F 3.84%, O 16.16%
 
Therap-Cat: Glucocorticoid.
Keywords: Glucocorticoid.

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