Clospirazine
Title: Clospirazine
CAS Registry Number: 24527-27-3
CAS Name: 8-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one
Additional Names: 8-[3-(2-chloro-10-phenothiazinyl)propyl]-3-oxo-1-thia-4,8-diazaspiro[4.5]decane; spiclomazine
Molecular Formula: C22H24ClN3OS2
Molecular Weight: 446.03
Percent Composition: C 59.24%, H 5.42%, Cl 7.95%, N 9.42%, O 3.59%, S 14.38%
Literature References: Prepn: Nakanishi et al., JP 69 23091; US 3574204 (1969, 1971 both to Yoshitomi). Pharmacological and metabolic studies: Nakanishi et al., J. Pharm. Soc. Jpn. 90, 800, 808 (1970); Imamura et al., ibid. 813. Review: Jpn. Med. Gaz. 8(11), 10 (1971).
Properties: mp 154-156° (acetone).
Melting point: mp 154-156° (acetone)
 
Derivative Type: Hydrochloride
CAS Registry Number: 27007-85-8
Manufacturers' Codes: APY-606
Trademarks: Diceplon (Yoshitomi); Disepron (Yoshitomi)
Properties: White to brownish, tasteless, odorless crystals or powder, mp 262-264° (dec). Sparingly sol in methanol; slightly sol in chloroform; very slightly sol in water. Decomposes slowly when exposed to light. LD50 in mice, rats (mg/kg): 3400, 2950 i.p.; >5490, >5490 s.c.; 3800, 4000 orally (Nakanishi, 1970).
Melting point: mp 262-264° (dec)
Toxicity data: LD50 in mice, rats (mg/kg): 3400, 2950 i.p.; >5490, >5490 s.c.; 3800, 4000 orally (Nakanishi, 1970)
 
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Phenothiazines.

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