Coenzyme A
Title: Coenzyme A
CAS Registry Number: 85-61-0
Additional Names: CoA
Molecular Formula: C21H36N7O16P3S
Molecular Weight: 767.53
Percent Composition: C 32.86%, H 4.73%, N 12.77%, O 33.35%, P 12.11%, S 4.18%
Literature References: An essential cofactor in enzymatic acetyl transfer reactions. Synthesized in cells from pantothenate, ATP and cysteine. Found ubiquitously in mammalian cells. Isoln from animal sources: Lipmann et al., J. Biol. Chem. 167, 869 (1947); 186, 235 (1950). Many microorganisms contain large amounts of the coenzyme. Isoln from Streptomyces fradiae: Kaplan, Lipmann, ibid. 174, 37 (1948). Purifications: De Vries et al., J. Am. Chem. Soc. 72, 4838 (1950); Gregory et al., ibid. 74, 854 (1952). Structure: Baddiley et al., Nature 171, 76 (1953). Total synthesis: Moffatt, Khorana, J. Am. Chem. Soc. 81, 1265 (1959); 83, 663 (1961); Shimizu et al., Chem. Pharm. Bull. 13, 1142 (1965). Reviews: Lipmann, Bacteriol. Rev. 17, 1-16 (1953); Baddiley, Adv. Enzymol. 16, 1 (1955); Jaenicke, Lynen in The Enzymes vol. 3, P. D. Boyer et al., Eds. (Academic Press, New York, 2nd ed., 1960) pp 3-103. Review of metabolism: J. D. Robishaw, J. R. Neely, Am. J. Physiol. 248, E1-E9 (1985); of clinical evaluations in hyperlipoproteinemia: A. Perin, G. Fraticelli, Int. J. Tissue React. 13, 111-114 (1991); of biochemical role in cellular toxicity: E. P. Brass, Chem. Biol. Interact. 90, 203-214 (1994).
Properties: White powder; characteristic thiol odor. May be dried in vacuo over phosphorus pentoxide at 34°. uv max: 259.5 nm (e 16800). Fairly strong acid. pK 9.6 (thiol); pK 6.4 (secondary phosphate); pK 4.0 (adenine NH3+). Soluble in water. Practically insol in ethanol, ether, acetone. Pure dry coenzyme is best stored in evacuated ampuls at room temp. Readily oxidized by air to the catalytically inactive disulfide.
pKa: pK 9.6 (thiol); pK 6.4 (secondary phosphate); pK 4.0 (adenine NH3+)
Absorption maximum: uv max: 259.5 nm (e 16800)

Others monographs:
Isopropyl EtherBenzilonium BromideIodininStrophanthin
EthanethiolLithium Tetracyanoplatinate(II)Styrene GlycolImidurea
TrimecaineSoapMaitotoxinTrypan Red
OsajinPumpkin Seed2-AminobenzothiazoleMethyl 4-Pyridyl Ketone Thiosemicarbazone
©2016 DrugLead US FDA&EMEA