Colestilan
Title: Colestilan
CAS Registry Number: 95522-45-5
CAS Name: 2-Methyl-1H-imidazole polymer with (chloromethyl)oxirane
Additional Names: 2-methylimidazole polymer with 1-chloro-2,3-epoxypropane; colestimide
Manufacturers' Codes: MCI-196
Trademarks: Cholebine (Mitsubishi)
Line Formula: (C4H6N2.C3H5ClO)n
Literature References: Bile acid sequestering anion exchange resin. Prepn: H. Toda, K. Kihara, JP Kokai 59138228 (1984 to Mitsubishi Petrochem.); and bile acid binding activity: H. Toda et al., J. Pharm. Sci. 77, 531 (1988). Series of articles on pharmacology and toxicology: Jpn. Pharmacol. Ther. 24, Suppl. 4, 1-181 (1996). Clinical evaluation in type II hyperlipoproteinemia: Y. Homma et al., Nutr. Metab. Cardiovasc. Dis. 6, 211 (1996); in hyperphosphatemia: S. Kurihara et al., Nephrol. Dial. Transplant. 20, 424 (2005).
Properties: Odorless, tasteless, white powder. Ion exchange capacity: 4.9 mEq/g. Particle size: 44-149 mm.
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Bile Acid Sequesterants; Ion-exchange Resin.

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