Cortivazol
Title: Cortivazol
CAS Registry Number: 1110-40-3
CAS Name: (11b,16a)-21-(Acetyloxy)-11,17-dihydroxy-6,16-dimethyl-2¢-phenyl-2¢H-pregna-2,4,6-trieno[3,2-c]pyrazol-20-one
Additional Names: 1,2,3,3a,3b,7,10,10a,10b,11,12,12a-dodecahydro-1,11-dihydroxy-2,5,10a,12a-tetramethyl-7-phenylcyclopenta[7,8]phenanthro[2,3-c]pyrazol-1-yl hydroxymethyl ketone acetate; 6,16a-dimethyl-11b,17a,21-trihydroxy-2¢-phenyl[3,2-c]pyrazolo-4,6-pregnadien-20-one 21-acetate
Manufacturers' Codes: MK-650; H-3625
Trademarks: Altim (Roussel Diamant); Diaster (Roussel Diamant); Dilaster (Hoechst)
Molecular Formula: C32H38N2O5
Molecular Weight: 530.65
Percent Composition: C 72.43%, H 7.22%, N 5.28%, O 15.08%
Literature References: Prepn: Fried et al., J. Am. Chem. Soc. 85, 236 (1963); Tishler et al., US 3067194 and US 3300483 (1962, l967 to Merck & Co.).
Properties: Double mp 160-165° and 229-230°; [a]D23 +14° (CHCl3). uv max (methanol): 283, 315 nm (e 15700, 19000).
Melting point: mp 160-165° and 229-230°
Optical Rotation: [a]D23 +14° (CHCl3)
Absorption maximum: uv max (methanol): 283, 315 nm (e 15700, 19000)
Therap-Cat: Glucocorticoid.
Keywords: Glucocorticoid.

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