Cosyntropin
Title: Cosyntropin
CAS Registry Number: 16960-16-0
CAS Name: a1-24-Corticotropin
Additional Names: b1-24-corticotropin; tetracosactide
Trademarks: Cortrosyn (Amphastar)
Molecular Formula: C136H210N40O31S
Molecular Weight: 2933.44
Percent Composition: C 55.68%, H 7.22%, N 19.10%, O 16.91%, S 1.09%
Literature References: Synthetic polypeptide corresponding to the first 24 amino acids of ACTH, q.v. Identification of activity: R. G. Shepherd et al., J. Am. Chem. Soc. 78, 5067 (1956). Synthesis: H. Kappeler, R. Schwyzer, Helv. Chim. Acta 44, 1136 (1961); eidem, ibid. 46, 1550 (1963); solid-state synthesis: R. Matsueda et al., J. Am. Chem. Soc. 97, 2573 (1975). Assessment of hormone levels for adrenal function in cats: M. E. Peterson et al., Res. Vet. Sci. 37, 331 (1984); in dogs: L. A. Frank et al., Domest. Anim. Endocrinol. 24, 43 (2003). Review as diagnostic aid in assessment of secondary adrenal insufficiency: T. A. M. Abdu, R. N. Clayton, Curr. Opin. Endocrinol. Diabetes 7, 116-121 (2000); in primary or secondary adrenal insufficiency: R. I. Dorin et al., Ann. Intern. Med. 139, 194-204, E205-E206 (2003).
 
Derivative Type: Hexaacetate
CAS Registry Number: 22633-88-1
CAS Name: a1-24-Corticotropin hexaacetate (salt)
Trademarks: Synacthen (Novartis)
Properties: [a]D22 -88 ±2° (c = 0.511 in 1% acetic acid). uv max (0.1 N NaOH): 283, 289 nm (e 8550, 8810).
Optical Rotation: [a]D22 -88 ±2° (c = 0.511 in 1% acetic acid)
Absorption maximum: uv max (0.1 N NaOH): 283, 289 nm (e 8550, 8810)
 
Therap-Cat: Diagnostic aid (adrenal function).
Therap-Cat-Vet: Diagnostic aid (adrenal function).
Keywords: Diagnostic Aid.

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