Desmopressin
Title: Desmopressin
CAS Registry Number: 16679-58-6
CAS Name: 1-(3-Mercaptopropanoic acid)-8-D-arginine vasopressin
Additional Names: 8-D-arginine-1-(3-mercaptopropanoic acid) vasopressin; 1-desamino-8-D-arginine vasopressin
Molecular Formula: C46H64N14O12S2
Molecular Weight: 1069.22
Percent Composition: C 51.67%, H 6.03%, N 18.34%, O 17.96%, S 6.00%
Literature References: Synthetic analog of vasopressin, q.v., with antidiuretic activity and decreased pressor effects. Improves hemostasis by increasing plasma levels of von Willebrand factor, factor VIII and tissue plasminogen activator, q.q.v. Prepn: M. Zaoral et al., FR 1540536; eidem, US 3497491 (1968, 1970 both to Ceskoslovenska Akad. Ved). Syntheses: R. L. Huguenin, R. A. Boissonnas, Helv. Chim. Acta 49, 695 (1966); M. Zaoral et al., Collect. Czech. Chem. Commun. 32, 1250 (1967). Review of clinical experience in bleeding disorders: P. M. Mannucci, Blood 90, 2515-2521 (1997); in treatment of nocturnal enuresis: P. E. V. van Kerrebroeck, BJU Int. 89, 420-425 (2002); of mechanism of hemostatic effects: J. E. Kaufmann, U. M. Vischer, J. Thromb. Haemostasis 1, 682-689 (2003).
Properties: [a]D25 +85.5 ± 2° (calculated for the free peptide).
Optical Rotation: [a]D25 +85.5 ± 2° (calculated for the free peptide)
 
Derivative Type: Monoacetate
CAS Registry Number: 62288-83-9
Trademarks: Adiuretin SD (Ferring); DDAVP (Ferring); Desmospray (Ferring); Minirin (Ferring); Octim (Ferring); Octostim (Ferring); Presinex (Pliva); Stimate (ZLB Behring)
Molecular Formula: C46H64N14O12S2.C2H4O2
Molecular Weight: 1129.27
Percent Composition: C 51.05%, H 6.07%, N 17.36%, O 19.84%, S 5.68%
Literature References: Occurs as the trihydrate.
 
Therap-Cat: Antidiuretic; hemostatic.
Keywords: Antidiuretic; Hemostatic.

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