Dibromochloropropane
Title: Dibromochloropropane
CAS Registry Number: 96-12-8
CAS Name: 1,2-Dibromo-3-chloropropane
Additional Names: 3-chloro-1,2-dibromopropane; DBCP
Manufacturers' Codes: OS-1897
Trademarks: Fumazone; Nemafume; Nemagon
Molecular Formula: C3H5Br2Cl
Molecular Weight: 236.33
Percent Composition: C 15.25%, H 2.13%, Br 67.62%, Cl 15.00%
Line Formula: ClCH2CHBrCH2Br
Literature References: Prepn: Darmstädter, Ann. 152, 320 (1869). Activity: C. W. McBeth, G. B. Bergeson, Plant Dis. Rep. 39, 223 (1955). Toxicity study: T. R. Torkelson et al., Toxicol. Appl. Pharmacol. 3, 545 (1961). Carcinogenicity studies: W. A. Olsen et al., J. Natl. Cancer Inst. 51, 1993 (1973); E. K. Weisburger, Environ. Health Perspect. 21, 7 (1977). Mutagenicity study: H. S. Rosenkranz, Bull. Environ. Contam. Toxicol. 14, 8 (1975). Review of toxicology and human exposure: Toxicological Profile for 1,2-Dibromo-3-chloropropane (PB93-110906, 1992) 164 pp.
Properties: Brown liq; pungent odor. bp 196°; bp16 78°; bp0.8 21°. d14 2.093. nD14 1.553. Vapor press at 21°: 0.8 mm Hg. Slightly sol in water; misc with oils, dichloropropane, isopropyl alcohol. LD50 in rats, mice (g/kg): 0.17, 0.26 orally (Torkelson).
Boiling point: bp 196°; bp16 78°; bp0.8 21°
Index of refraction: nD14 1.553
Density: d14 2.093
Toxicity data: LD50 in rats, mice (g/kg): 0.17, 0.26 orally (Torkelson)
CAUTION: Potential symptoms of overexposure are drowsiness; nausea, vomiting; irritation of eyes, nose, throat and skin; pulmonary edema; liver and kidney injury; sterility. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 92. See also Clinical Toxicology of Commercial Products, R. E. Gosselin et al., Eds. (Williams & Wilkins, Baltimore, 5th ed., 1984) Section II, pp 167-168. This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-81.
Use: Soil fumigant; nematocide; intermediate in organic synthesis.

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