Dihexyverine
Title: Dihexyverine
CAS Registry Number: 561-77-3
CAS Name: [1,1¢-Bicyclohexyl]-1-carboxylic acid 2-(1-piperidinyl)ethyl ester
Additional Names: 1-cyclohexylcyclohexanecarboxylic acid b-piperidinoethyl ester; dicyclohexylacetic acid 2-piperidinoethyl ester; dihexiverine
Molecular Formula: C20H35NO2
Molecular Weight: 321.50
Percent Composition: C 74.72%, H 10.97%, N 4.36%, O 9.95%
Literature References: Anticholinergic. Prepn: Kopp, Tchoubar, Bull. Soc. Chim. Fr. 1952, 84. Pharmacology: Buchel et al., Arch. Sci. Physiol. 16, 57 (1962); 21, 537 (1967); Guyonneau, Med. Exp. 6, 245 (1962).
 
Derivative Type: Hydrochloride
CAS Registry Number: 5588-25-0
Manufacturers' Codes: JL-1078
Trademarks: Metaspas (Leeming); Diverine (Courtois); Olimplex (Vaillant-Defresne); Seclin (Panthox & Burck); Dispas (Ankerfarm); Neospasmina (Biofarmacoterapico); Spasmodex (Crinex); Spasmalex
Molecular Formula: C20H35NO2.HCl
Molecular Weight: 357.96
Percent Composition: C 67.11%, H 10.14%, N 3.91%, O 8.94%, Cl 9.90%
Properties: Crystals, mp 175° (copper block). mp 200° (capillary). LD50 i.p. in mice: 212 mg/kg (Buchel).
Melting point: mp 175° (copper block); mp 200° (capillary)
Toxicity data: LD50 i.p. in mice: 212 mg/kg (Buchel)
 
Therap-Cat: Antispasmodic.
Keywords: Antimuscarinic; Antispasmodic.

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