Diloxanide
Title: Diloxanide
CAS Registry Number: 579-38-4
CAS Name: 2,2-Dichloro-N-(4-hydroxyphenyl)-N-methylacetamide
Additional Names: 2,2-dichloro-4¢-hydroxy-N-methylacetanilide; N-dichloroacet-4-hydroxy-N-methylanilide; 4-hydroxy-N-methyldichloroacetanilide
Trademarks: Entamide (Boots)
Molecular Formula: C9H9Cl2NO2
Molecular Weight: 234.08
Percent Composition: C 46.18%, H 3.88%, Cl 30.29%, N 5.98%, O 13.67%
Literature References: Prepn: P. Oxley et al., US 2912438 (1959 to Boots Pure Drug). Spectrophotometric determn in 2-component tablet formulation: S. M. Galal et al., J. Pharm. Belg. 46, 315 (1991). Clinical trial of combination with metronidazole, q.v., in amoebiasis and giardiasis: H. Qureshi et al., J. Int. Med. Res. 25, 167 (1997). Review of clinical experience: J. B. McAuley et al., Clin. Infect. Dis. 15, 464-468 (1992).
Properties: Crystals from ethyl acetate, mp 175°.
Melting point: mp 175°
 
Derivative Type: Furoate
CAS Registry Number: 3736-81-0
Additional Names: Diloxanide 2-furoic acid ester
Trademarks: Furamide (Knoll)
 
Therap-Cat: Antiamebic.
Keywords: Antiamebic.

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