Dimenhydrinate
Title: Dimenhydrinate
CAS Registry Number: 523-87-5
CAS Name: 8-Chloro-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione compd with 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
Additional Names: 2-(benzhydryloxy)-N,N-dimethylethylamine 8-chlorotheophyllinate; b-dimethylaminoethyl benzhydryl ether 1,3-dimethyl-8-chloroxanthine; diphenhydramine 8-chlorotheophyllinate; N,N-dimethyl-2-diphenylmethoxyethylamine 8-chlorotheophyllinate; O-benzhydryldimethylaminoethanol 8-chlorotheophyllinate; chloranautine
Trademarks: Amosyt (Abigo); Anautine; Andramine; Antemin (Streuli); Diamarin; Dimate (Tutag); Dramamine (Searle); Dramarin; Dramocen (Central Pharm.); Dramyl; Emedyl; Emes; Epha (Woelm); Gravol (Horner); Menhydrinate; Travel-Gum (Chemofux); Travelin; Travelmin; Vomex A (Yamanouchi); Xamamina; Faston (Duphar)
Molecular Formula: C24H28ClN5O3
Molecular Weight: 469.96
Percent Composition: C 61.34%, H 6.01%, Cl 7.54%, N 14.90%, O 10.21%
Literature References: Prepn: Cusic, Science 109, 574 (1949); Cusic, US 2499058 and US 2534813 (1950 to Searle).
Properties: Crystals, mp 102-107°. Freely sol in alcohol, chloroform. Soluble in benzene. Soly in water: about 3 mg/ml. Almost insol in ether. A satd aq soln has a pH between 6.8 and 7.3.
Melting point: mp 102-107°
Therap-Cat: Antiemetic.
Therap-Cat-Vet: Has been used as an antiemetic.
Keywords: Antiemetic.

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