Dimethicone
Title: Dimethicone
CAS Registry Number: 9006-65-9
Additional Names: Dimethyl polysiloxane; dimeticon; polydimethylsiloxane; a-(trimethylsilyl)-w-methylpoly[oxy(dimethylsilylene)]
Literature References: Silicone oil consisting of a mixture of fully methylated linear siloxane polymers end-blocked with trimethylsiloxy units. Prepn of homologous liquid methyl siloxane polymers: J. F. Hyde, US 2441098 (1948 to Corning Glass). Dimethicone mixed with silicon dioxide is known as simethicone. Clinical evaluation of simethicone in functional upper GI disease: J. E. Bernstein, A. M. Kasich, J. Clin. Pharmacol. 14, 617 (1974). Stability of simethicone + antacid mixtures in pharmaceutical preparations: J. A. Rider, Curr. Ther. Res. 52, 681 (1992). Review of use of dimethicones in skin and hair products: A. Disapio, P. Fridd, Int. J. Cosmet. Sci. 10, 75-89 (1988). Review of medical use in soft-tissue augmentation: V. J. Selmanowitz, N. Orentreich, J. Dermatol. Surg. Oncol. 3, 597-611 (1977); D. M. Duffy, Adv. Dermatol. 5, 93-109 (1990). See also: Silicones.
Properties: Clear colorless liquids. Viscosity increases with degree of polymerization. Immiscible with water, alcohol. Miscible with chloroform, ether.
 
Derivative Type: Mixture with silicon dioxide
CAS Registry Number: 8050-81-5
Additional Names: Simethicone; activated dimethicone
Trademarks: Antifoam A (Dow); Baros (Horii); Colicon (Resse); Endo-Paractol (Temmler); Gas-X (Sandoz); Infacol (Pharmax); Lefax (Asche); Mylicon (J & J-Merck); Phasil (Reed & Carnrick); Phazyme (Reed & Carnrick); sab simplex (Pfizer); Silain (Wyeth)
Properties: Average number of dimethylsiloxane units is 200 to 350. mol wt 14000-21000. Gray, translucent, viscous liquid. Insol in water, alcohol.
 
Derivative Type: Dimethicone 350
Properties: Specific polydimethylsiloxane characterized by the following properties. Viscosity (25°): 350 cSt. d 0.965-0.973. nD25 1.4013-1.4053.
Index of refraction: nD25 1.4013-1.4053
Density: d 0.965-0.973
 
Use: Oleaginous ointment base, skin protectant, antifoaming agent; prosthetic aid (soft tissue).
Therap-Cat: Antiflatulent.
Therap-Cat-Vet: Antibloating agent.
Keywords: Antiflatulent.

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