EEDQ
Title: EEDQ
CAS Registry Number: 16357-59-8
CAS Name: 2-Ethoxy-1(2H)-quinolinecarboxylic acid ethyl ester
Additional Names: N-carbethoxy-2-ethoxy-1,2-dihydroquinoline; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
Manufacturers' Codes: BC-681
Molecular Formula: C14H17NO3
Molecular Weight: 247.29
Percent Composition: C 68.00%, H 6.93%, N 5.66%, O 19.41%
Literature References: Coupling agent used in the synthesis of peptides: Belleau, Malek, J. Am. Chem. Soc. 90, 1651 (1968); Yajima, Kawatani, Chem. Pharm. Bull. 19, 1905 (1971); Sipos, Gaston, Synthesis 1971, 321. Preparation: Weinberg, US 3389142 and US 3452140 (1968, 1969, to Bristol-Myers). Has CNS depressant activity: Belleau, J. Am. Chem. Soc. 90, 823 (1968). Pharmacological studies: Martel et al., Can. J. Physiol. Pharmacol. 47, 909 (1969); Chang et al., Pharmacol. Res. Commun. 2, 63 (1970); Weissman, Muren, J. Med. Chem. 14, 49 (1971).
Properties: mp 56-57°. bp0.1 125-128°.
Melting point: mp 56-57°
Boiling point: bp0.1 125-128°
Use: In the synthesis of peptides.

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