Ethacridine
Title: Ethacridine
CAS Registry Number: 442-16-0
CAS Name: 7-Ethoxy-3,9-acridinediamine
Additional Names: 6,9-diamino-2-ethoxyacridine; 2,5-diamino-7-ethoxyacridine; 2-ethoxy-6,9-diaminoacridine; etakridin
Molecular Formula: C15H15N3O
Molecular Weight: 253.30
Percent Composition: C 71.13%, H 5.97%, N 16.59%, O 6.32%
Literature References: Prepn: DE 364033; DE 364037; DE 393411; DE 395683 (1922); Frdl. 14, 804, 807-812; A. Albert, W. Gledhill, J. Soc. Chem. Ind. 61, 159 (1942). Toxicity: S. D. Rubbo, Br. J. Exp. Pathol. 28, 1 (1947); N. J. Joshi et al., Indian J. Exp. Biol. 16, 1038 (1978). Pharmacokinetics: T. J. Rising et al., Arzneim.-Forsch. 27, 872 (1977). Use in protein analysis: R. H. Yue et al., Thromb. Diath. Haemorrh. 31, 439 (1974); F. Franek, Methods Enzymol. 121, 631-638 (1986); in serological detection of Brucella sp.: J. D. Huber, P. Nicoletti, Am. J. Vet. Res. 47, 1529 (1986). Clinical evaluation in diarrhea: N. Madanagopalan et al., Curr. Ther. Res. 18, 546 (1975); R. Raedsch et al., Klin. Wochenschr. 69, 863 (1991); as an abortifacient: S. Gardo, M. Nagy, Arch. Gynecol. Obstet. 247, 39 (1990).
Properties: Orange-yellow crystals from 50% alc. mp 226°.
Melting point: mp 226°
 
Derivative Type: Lactate monohydrate
CAS Registry Number: 6402-23-9
Additional Names: Acrinol
Trademarks: Rimaon; Rivanol (Winthrop); Vucine; Acrolactine; Ethodin (Winthrop); Metifex (Cassella-med)
Molecular Formula: C15H15N3O.C3H6O3.H2O
Molecular Weight: 361.39
Percent Composition: C 59.82%, H 6.41%, N 11.63%, O 22.14%
Properties: Light yellow crystals from 90% alcohol + ether. Darkens at 200°, mp 235°. Slowly sol in 15 parts water; sol in 9 parts boiling water; in 110 parts alcohol at 22°, in 100 parts boiling alcohol. Solns are yellow, fluorescent and stable to boiling. LD50 s.c. in mice: 0.12 g/kg (Rubbo).
Melting point: mp 235°
Toxicity data: LD50 s.c. in mice: 0.12 g/kg (Rubbo)
 
Use: Reagent in serological testing and protein chemistry.
Therap-Cat: Antiseptic. Abortifacient.
Keywords: Antiseptic/Disinfectant; Dyes.

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