Fluorometholone
Title: Fluorometholone
CAS Registry Number: 426-13-1
CAS Name: (6a,11b)-9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
Additional Names: 21-desoxy-9a-fluoro-6a-methylprednisolone; 21-desoxy-6a-methyl-9a-fluoroprednisolone; fluormetholon
Trademarks: Delmeson (Aventis); Efflumidex (Allergan); Fluaton (Tubi Lux); Flumetholon (Santen); Fluor-Op (Novartis); FML (Allergan)
Molecular Formula: C22H29FO4
Molecular Weight: 376.46
Percent Composition: C 70.19%, H 7.76%, F 5.05%, O 17.00%
Literature References: Prepn: F. H. Lincoln et al., US 2867637 (1959 to Upjohn). Prepn of acetate and other esters: B. J. Magerlein et al., US 3038914 (1962 to Upjohn). Pharmacology of acetate: A. Kupferman et al., Arch. Ophthalmol. 100, 640 (1982). HPLC determn: H. Tokunaga et al., Chem. Pharm. Bull. 32, 4012 (1984). Clinical evaluation in ocular inflammation: H. M. Leibowitz et al., Ann. Ophthalmol. 16, 1110 (1984).
Properties: Crystals from acetone, mp 292-303°.
Melting point: mp 292-303°
 
Derivative Type: 17-Acetate
CAS Registry Number: 3801-06-7
Trademarks: Eflone (Novartis)
Molecular Formula: C24H31FO5
Molecular Weight: 418.50
Percent Composition: C 68.88%, H 7.47%, F 4.54%, O 19.12%
Properties: Crystals from ethyl acetate + hexanes, mp 230-232°. [a]D +28° (chloroform).
Melting point: mp 230-232°
Optical Rotation: [a]D +28° (chloroform)
 
Therap-Cat: Glucocorticoid; anti-inflammatory.
Keywords: Glucocorticoid.

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