Flutamide
Title: Flutamide
CAS Registry Number: 13311-84-7
CAS Name: 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Additional Names: a,a,a-trifluoro-2-methyl-4¢-nitro-m-propionotoluidide; 4¢-nitro-3¢-trifluoromethylisobutyranilide; niftolid
Manufacturers' Codes: Sch-13521
Trademarks: Drogenil (Schering); Eulexin (Schering); Euflex (Schering); Flucinom (Schering); Flutamin (Merck KGaA); Fugerel (Schering)
Molecular Formula: C11H11F3N2O3
Molecular Weight: 276.21
Percent Composition: C 47.83%, H 4.01%, F 20.63%, N 10.14%, O 17.38%
Literature References: Prepn: Baker et al., J. Med. Chem. 10, 93 (1967); Neri, Topliss, DE 2130450 (1972 to Sherico), C.A. 78, 58091g (1973); Gold, DE 2261293; idem, US 3847988 (1973, 1974 both to Schering). Activity studies: Neri et al., Endocrinology 91, 427 (1972); Peets et al., ibid. 94, 532 (1974); B. A. Gladue, L. G. Clemens, Endocrinology 106, 1917 (1980). Effect in prostatic cancer: P. C. Sogani, W. F. Whitmore, J. Urol. 122, 640 (1979). Clinical evaluation in pancreatic cancer: B. A. Greenway, Br. Med. J. 316, 1935 (1998).
Properties: Crystals from benzene, mp 111.5-112.5°.
Melting point: mp 111.5-112.5°
Therap-Cat: Antiandrogen; antineoplastic (hormonal).
Therap-Cat-Vet: Antiandrogen.
Keywords: Antiandrogen; Antineoplastic (Hormonal); Antiandrogens.

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