Formebolone
Title: Formebolone
CAS Registry Number: 2454-11-7
CAS Name: 11a,17b-Dihydroxy-17-methyl-3-oxoandrosta-1,4-diene-2-carboxaldehyde
Additional Names: 2-formyl-17a-methylandrosta-1,4-diene-11a,17b-diol-3-one; 2-formyl-11a-hydroxy-D1-methyltestosterone; formyldienolone
Trademarks: Esiclene (LPB Braglia)
Molecular Formula: C21H28O4
Molecular Weight: 344.44
Percent Composition: C 73.23%, H 8.19%, O 18.58%
Literature References: Prepn: Canonica et al., Gazz. Chim. Ital. 95, 138 (1968); Gomarasca, GB 1168931; FR 1584960 (1969, 1970 both to Lab. Prod. Biol. Braglia), C.A. 72, 90742g (1970); 73, 131212a (1970). Pharmacology: idem, Minerva Med. 62, 842 (1971); Vaccari, Livini, ibid. 846; De Marchi et al., Arzneim.-Forsch. 23, 1583 (1973). GC/MS determn of metabolites in urine: R. Massé et al., Anal. Chim. Acta 247, 211 (1991). Toxicological studies: Travella, Gazz. Int. Med. Chir. 76, 400 (1971), C.A. 75, 30792a (1971).
Properties: Crystals from ethyl acetate, mp 209-212°. [a]D25 -105° (CHCl3). Water soluble. Approx LD50 in rats, mice (mg/kg): 104, 187 i.p.; 270, 293 s.c.; orally in rats: >1000 (Travella).
Melting point: mp 209-212°
Optical Rotation: [a]D25 -105° (CHCl3)
Toxicity data: Approx LD50 in rats, mice (mg/kg): 104, 187 i.p.; 270, 293 s.c.; orally in rats: >1000 (Travella)
 
Derivative Type: 11-b-Epimer
Properties: mp 95-103° from ethyl ether-petr ether.
Melting point: mp 95-103°
 
NOTE: This is a controlled substance (anabolic steroid): 21 CFR, 1308.13, as defined in 1300.01.
Therap-Cat: Anabolic.
Keywords: Anabolic.

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