Fotemustine
Title: Fotemustine
CAS Registry Number: 92118-27-9
CAS Name: [1-[[[(2-Chloroethyl)nitrosoamino]carbonyl]amino]ethyl]phosphonic acid diethyl ester
Additional Names: (±)-diethyl [1-[3-(2-chloroethyl)-3-nitrosoureido]ethyl]phosphonate; 1-[N-(2-chloroethyl)-N-nitrosoureido]ethylphosphonic acid diethyl ester
Manufacturers' Codes: S-10036
Trademarks: Muphoran (Servier)
Molecular Formula: C9H19ClN3O5P
Molecular Weight: 315.69
Percent Composition: C 34.24%, H 6.07%, Cl 11.23%, N 13.31%, O 25.34%, P 9.81%
Literature References: Amino acid-linked nitrosourea alkylating agent. Prepn: G. Lavielle, C. Cudennec, FR 2536075; eidem, US 4567169 (1984, 1986 both to ADIR). Clinical evaluation in advanced cancers: D. Khayat et al., Cancer Res. 47, 6782 (1987); in disseminated malignant melanoma: D. Khayat et al., J. Natl. Cancer Inst. 80, 1407 (1988).
Properties: mp 85°.
Melting point: mp 85°
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Nitrosoureas.

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