Iodoform
Title: Iodoform
CAS Registry Number: 75-47-8
CAS Name: Triiodomethane
Molecular Formula: CHI3
Molecular Weight: 393.73
Percent Composition: C 3.05%, H 0.26%, I 96.69%
Literature References: Prepn from acetone, sodium hypochlorite, potassium iodide, and sodium hydroxide: Glass, Q. J. Pharm. Pharmacol. 8, 351 (1935); from chloroform + methyl iodide: Soroos, Hinkamp, J. Am. Chem. Soc. 67, 1642 (1945); by electrolysis: Glasstone, Ind. Chem. 7, 315 (1931). Description of the iodoform reaction: Seelye, Turney, J. Chem. Educ. 36, 572 (1959). Toxicity study: Kutob, Plaa, Toxicol. Appl. Pharmacol. 4, 354 (1962).
Properties: Yellow powder or crystals; mp ~120°; dec at high temp with evolution of iodine. Unctuous touch; characteristic, disagreeable odor. Volatile with steam. d 4.1. Very slightly sol in water. One gram dissolves in 60 ml cold alcohol, 16 ml boiling alcohol, 10 ml chloroform, 7.5 ml ether, 80 ml glycerol, 3 ml carbon disulfide, 34 ml olive oil; freely sol in benzene, acetone, slightly sol in petr ether. LD50 s.c. in mice: 1.6 mmoles/kg (Kutob, Plaa).
Melting point: mp ~120°
Density: d 4.1
Toxicity data: LD50 s.c. in mice: 1.6 mmoles/kg (Kutob, Plaa)
CAUTION: Potential symptoms of overexposure are irritation of eyes and skin; lightheadedness, dizziness, nausea, incoordination, CNS depression; dyspnea; liver, kidney and heart damage; visual disturbances. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 172.
Therap-Cat: Anti-infective (topical).
Therap-Cat-Vet: Antiseptic, disinfectant for superficial lesions and in the female reproductive tract.
Keywords: Antiseptic/Disinfectant; Halogens/Halogen Containing Compounds.

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