Isocarboxazid
Title: Isocarboxazid
CAS Registry Number: 59-63-2
CAS Name: 5-Methyl-3-isoxazolecarboxylic acid 2-benzylhydrazide
Additional Names: 3-(N-benzylhydrazinocarbonyl)-5-methylisoxazole; 1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl)hydrazine
Manufacturers' Codes: Ro-5-0831
Trademarks: Marplan (Roche)
Molecular Formula: C12H13N3O2
Molecular Weight: 231.25
Percent Composition: C 62.33%, H 5.67%, N 18.17%, O 13.84%
Literature References: Monoamine oxidase inhibitor. Prepn: Gardner, Wenis, US 2908688 (1959 to Hoffmann-La Roche); J. Med. Pharm. Chem. 2, 133 (1960). Comprehensive description: B. C. Rudy, B. Z. Senkowski, Anal. Profiles Drug Subs. 2, 295-314 (1973).
Properties: Crystals from methanol, practically tasteless. mp 105-106°. Very sparingly sol in hot water (0.05%), somewhat more (1 to 2%) in 95% alc, in glycerol, in propylene glycol.
Melting point: mp 105-106°
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Hydrazides/Hydrazines; Monoamine Oxidase Inhibitor.

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