Leptophos
Title: Leptophos
CAS Registry Number: 21609-90-5
CAS Name: Phenylphosphonothioic acid O-(4-bromo-2,5-dichlorophenyl) O-methyl ester
Additional Names: O-(4-bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate; O-methyl O-2,5-dichloro-4-bromophenyl phenylthiophosphonate
Manufacturers' Codes: VCS-506
Trademarks: Abar (Velsicol); Phosvel (Velsicol)
Molecular Formula: C13H10BrCl2O2PS
Molecular Weight: 412.07
Percent Composition: C 37.89%, H 2.45%, Br 19.39%, Cl 17.21%, O 7.77%, P 7.52%, S 7.78%
Literature References: Prepn and use as an insecticide: Richter, Hanna; US 3459836, US 3551563, US 3577482 (1969, 1970, 1971, all to Velsicol). Metabolism in mice and on cotton plants: Holmstead et al., Arch. Environ. Contam. Toxicol. 1, 133 (1973). Toxicological studies in mammals: Kamel et al., J. Eur. Toxicol. 6, 70 (1973); Abou-Donia et al., Experientia 30, 63 (1974); T. B. Gaines, R. E. Linder, Fundam. Appl. Toxicol. 7, 299 (1986).
Properties: Tan waxy solid. mp range 55-67°. Sp gr at 25° = 1.53. Solubility at 25° (gm/100 ml): benzene, 133; xylene, 73; acetone, 62; cyclohexane,14; heptane, 7; isopropanol, 2.4; water, 0.03 ppm. Stable to acids; hydrolyzed slowly under strongly alkaline conditions. LD50 in adult male, female rats (mg/kg): 19, 20 orally (Gaines, Linder).
Melting point: mp range 55-67°
Toxicity data: LD50 in adult male, female rats (mg/kg): 19, 20 orally (Gaines, Linder)
Use: Insecticide.

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