Lonazolac
Title: Lonazolac
CAS Registry Number: 53808-88-1
CAS Name: 3-(4-Chlorophenyl)-1-phenyl-1H-pyrazole-4-acetic acid
Molecular Formula: C17H13ClN2O2
Molecular Weight: 312.75
Percent Composition: C 65.29%, H 4.19%, Cl 11.34%, N 8.96%, O 10.23%
Literature References: Prepn: R. A. Newberry, GB 1373212 (1974 to Wyeth), C.A. 82, 72987t (1975); G. Rainer, US 4146721 (1979 to Byk Gulden); G. Rainer et al., Arzneim.-Forsch. 31, 649 (1981). Pharmacology: R. Riedel, ibid. 655. Clinical studies: G. Lonauer et al., Z. Rheumatol. 40, 161 (1981); W. Siegmeth, P. Placheta, Wien. Klin. Wochenschr. 94, 145 (1982).
Properties: Crystals from ethanol/water, mp 150-151°. uv max (methanol): 281 nm (e 24800); (0.1N NaOH): 281 nm (e 23700). pKa 4.3. LD50 in male mice, rats (mg/kg): 195, 165 i.v. (Riedel).
Melting point: mp 150-151°
pKa: pKa 4.3
Absorption maximum: uv max (methanol): 281 nm (e 24800); (0.1N NaOH): 281 nm (e 23700)
Toxicity data: LD50 in male mice, rats (mg/kg): 195, 165 i.v. (Riedel)
 
Derivative Type: Calcium salt
CAS Registry Number: 75821-71-5
Trademarks: Argun L (Merckle); Irritren (Byk Gulden)
Molecular Formula: C34H24CaCl2N4O4
Molecular Weight: 663.56
Percent Composition: C 61.54%, H 3.65%, Ca 6.04%, Cl 10.69%, N 8.44%, O 9.64%
Properties: Solid, melts between 270-290° (dec). uv max (0.1N NaOH): 280 nm (e 46400). LD50 in male, female mice, male, female rats (mg/kg): 670, 845, 730, 1000 orally (Riedel).
Melting point: melts between 270-290° (dec)
Absorption maximum: uv max (0.1N NaOH): 280 nm (e 46400)
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 670, 845, 730, 1000 orally (Riedel)
 
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives.

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