Marbofloxacin
Title: Marbofloxacin
CAS Registry Number: 115550-35-1
CAS Name: 9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[3,2,1-ij][4,1,2]benzoxadiazine-6-carboxylic acid
Trademarks: Marbocyl (V oquinol); Zeniquin (Pfizer)
Molecular Formula: C17H19FN4O4
Molecular Weight: 362.36
Percent Composition: C 56.35%, H 5.29%, F 5.24%, N 15.46%, O 17.66%
Literature References: Fluorinated quinolone antibacterial. Prepn: M. Aoki et al., EP 259804; K. Yokose et al., US 4801584 (1987, 1989 both to Hoffmann-LaRoche). HPLC determn in plasma: M. A. Garcia et al., J. Chromatogr. B 729, 157 (1999). Evaluation of experimental surgical infection in dogs: P. Gruet et al., Vet. Rec. 140, 199 (1997). Pharmacokinetics and efficacy in cattle: C. Eyett-Burton et al., Cattle Practice 5, 289 (1997). Pharmacokinetics in renally impaired dogs: H. P. Lefebvre et al., J. Vet. Pharmacol. Ther. 21, 453 (1998).
Properties: Crystals from methanol, mp 268-269° (dec).
Melting point: mp 268-269°
Therap-Cat-Vet: Antibacterial.

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