MDE
Title: MDE
CAS Registry Number: 82801-81-8
CAS Name: N-Ethyl-a-methyl-1,3-benzodioxole-5-ethanamine
Additional Names: (±)-N-ethyl-3,4-methylenedioxyamphetamine; N-ethyl-3,4-methylenedioxyphenylisopropylamine; 3,4-methylenedioxyethamphetamine; MDEA; "Eve"
Molecular Formula: C12H17NO2
Molecular Weight: 207.27
Percent Composition: C 69.54%, H 8.27%, N 6.76%, O 15.44%
Literature References: Entactogen; N-ethyl derivative of MDA, q.v. Prepn: U. Braun et al., J. Pharm. Sci. 69, 192 (1980); F. T. Noggle, Jr. et al, J. Assoc. Off. Anal. Chem. 70, 981 (1987). Pharmacology: M. Johnson et al., Biochem. Pharmacol. 38, 4333 (1989); K. M. Hegadoren et al., Psychopharmacology 118, 295 (1995). Determn in human urine using immunoassays and GC/MS: G. W. Kunsman et al., J. Anal. Toxicol. 14, 149 (1990). HPLC determn in tablets: M. Longo et al., J. Liq. Chromatogr. 17, 649 (1994). Impact on public health and abuse potential: G. P. Dowling et al., J. Am. Med. Assoc. 257, 1615 (1987); R. O. Bost, J. Forensic Sci. 33, 576 (1988); B. Tehan et al., Anaesthesia 48, 507 (1993). Psychological effects in humans: L. Hermle et al., Neuropsychopharmacology 8, 171 (1993). Neuroendocrine and cardiovascular effects in humans: E. Gouzoulis et al., ibid. 187.
Properties: Viscous, colorless oil. bp0.2 85-95°.
Boiling point: bp0.2 85-95°
 
Derivative Type: Hydrochloride
CAS Registry Number: 74341-78-9
Properties: Fine white granular solid from ethanol-ether, mp 197-198° (Noggle). Also reported as white solid from isopropanol-ether, mp 201-202° (Braun). LD50 i.p. in mice: 102 mg/kg (Noggle).
Melting point: mp 197-198° (Noggle); mp 201-202° (Braun)
Toxicity data: LD50 i.p. in mice: 102 mg/kg (Noggle)
 
NOTE: This is a controlled substance (hallucinogen): 21 CFR, 1308.11.

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