Mebrofenin
Title: Mebrofenin
CAS Registry Number: 78266-06-5
CAS Name: N-[2-[(3-Bromo-2,4,6-trimethylphenyl)amino]-2-oxoethyl]-N-(carboxymethyl)glycine
Additional Names: [[[(3-bromomesityl)carbamoyl]methyl]imino]diacetic acid; N-(3-bromo-2,4,6-trimethylacetanilide)iminodiacetic acid; trimethylbromo-IDA
Trademarks: Choletec (BMS)
Molecular Formula: C15H19BrN2O5
Molecular Weight: 387.23
Percent Composition: C 46.53%, H 4.95%, Br 20.63%, N 7.23%, O 20.66%
Literature References: Prepn: A. D. Nunn, M. D. Loberg, BE 891534; eidem, US 4418208 (1982, 1983 both to Squibb). Physicochemical properties of 99mtechnetium complex used for hepatobiliary tract imaging: A. D. Nunn et al., J. Nucl. Med. 24, 423 (1983). Pharmacokinetics in rats: A. R. Fritzberg et al., J. Pharm. Sci. 73, 1861 (1984). Evaluation as cholescintigraphic imaging agent in animals: A. van Aswegen et al., Nucl. Med. Biol. 13, 509 (1986); J. Kapuscinski et al., Nucl. Med. 25, 188 (1986); in humans: W. C. Klingensmith et al., Radiology 146, 181 (1983). Toxicity study: M. Jiang et al., Zhonghua Heyixue Zazhi 4, 214 (1984), C.A. 102, 42241j (1985).
Properties: Crystals from ethanol, mp 198-200°. LD50 in mice, rats (mg/kg): 213.8, 226.4 i.v. (Jiang).
Melting point: mp 198-200°
Toxicity data: LD50 in mice, rats (mg/kg): 213.8, 226.4 i.v. (Jiang)
Therap-Cat: 99mTc complex as diagnostic aid (radioactive imaging agent).

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