Meclizine
Title: Meclizine
CAS Registry Number: 569-65-3
CAS Name: 1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine
Additional Names: 1-(p-chloro-a-phenylbenzyl)-4-(m-methylbenzyl)piperazine; 1-(p-chlorobenzhydryl)-4-(m-methylbenzyl)piperazine; 1-(p-chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine; meclozine; parachloramine
Molecular Formula: C25H27ClN2
Molecular Weight: 390.95
Percent Composition: C 76.80%, H 6.96%, Cl 9.07%, N 7.17%
Literature References: Synthesis: Morren, BE 502889 (1951); GB 705979 (1954), US 2709169 (1955 to U.C.B.). Outline of reactions: Grivsky, Ind. Chim. Belge 17, 735 (1952). Clinical evaluation in vertigo: B. Cohen, J. M. B. Vianney de Jong, Arch. Neurol. 27, 129 (1972).
Properties: bp2 230°.
Boiling point: bp2 230°
 
Derivative Type: Dihydrochloride monohydrate
CAS Registry Number: 31884-77-2
Manufacturers' Codes: UCB-5062
Trademarks: Ancolan (Boots); Antivert (Pfizer); Bonamine (Pfizer); Bonine (Insight); Calmonal (BMS); Peremesin (BMS); Postafen (UCB)
Molecular Formula: C25H27ClN2.2HCl.H2O
Molecular Weight: 481.89
Percent Composition: C 62.31%, H 6.48%, Cl 22.07%, N 5.81%, O 3.32%
Properties: Freely sol in chloroform, pyridine; slightly sol in dil acids, alc. Practically insol in water (0.1 gm/100 ml), ether.
 
Therap-Cat: Antiemetic.
Therap-Cat-Vet: Antiemetic.
Keywords: Antiemetic.

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