Mefruside
Title: Mefruside
CAS Registry Number: 7195-27-9
CAS Name: 4-Chloro-N1-methyl-N1-[(tetrahydro-2-methyl-2-furanyl)methyl]-1,3-benzenedisulfonamide
Additional Names: 4-chloro-N1-methyl-N1-(tetrahydro-2-methylfurfuryl)-m-benzenedisulfonamide; 2-[(4-chloro-N1-methyl-3-sulfamoylbenzenesulfonamido)methyl]-2-methyltetrahydrofuran; N-(4-chloro-3-sulfamoylbenzenesulfonyl)-N-methyl-2-furfurylamine
Manufacturers' Codes: B-1500
Trademarks: Baycaron (Bayer)
Molecular Formula: C13H19ClN2O5S2
Molecular Weight: 382.88
Percent Composition: C 40.78%, H 5.00%, Cl 9.26%, N 7.32%, O 20.89%, S 16.75%
Literature References: Prepn: H. Horstmann et al., GB 1031916; eidem, US 3356692 (1966, 1967 to Bayer AG); of dl-, d-, and l-forms, eidem, Arzneim.-Forsch. 17, 653 (1967).
 
Derivative Type: dl-Form
Properties: Crystals, mp 149-150°.
Melting point: mp 149-150°
 
Derivative Type: d-Form
Properties: Crystals, mp 146°. [a]20578 +5.4° (c = 2.026 in methanol).
Melting point: mp 146°
Optical Rotation: [a]20578 +5.4° (c = 2.026 in methanol)
 
Derivative Type: l-Form
Properties: Crystals, mp 146°. [a]20578 -5.5° (c = 2.100 in methanol). More active as a diuretic than the d-form.
Melting point: mp 146°
Optical Rotation: [a]20578 -5.5° (c = 2.100 in methanol)
 
Therap-Cat: Diuretic.
Keywords: Diuretic; Sulfonamide Derivatives.

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