CAS Registry Number: 100-92-5
CAS Name: N,a,a-Trimethylbenzeneethanamine
Additional Names: 2-methylamino-2-methyl-1-phenylpropane; N-methyl-w-phenyl-tert-butylamine; N,a,a-trimethylphenethylamine
Molecular Formula: C11H17N
Molecular Weight: 163.26
Percent Composition: C 80.92%, H 10.50%, N 8.58%
Literature References: a-Adrenergic agonist. Prepd by hydrogenating 1-chloro-2-methylamino-2-methyl-1-phenylpropane hydrochloride in methanol in the presence of palladium barium carbonate: Bruce, Szabo, US 2597445 (1952 to Wyeth). Alternate process: Abel et al., US 2590079 (1952 to Wyeth). Pharmacology: D. K. Eckfeld et al., J. Am. Pharm. Assoc. 43, 705 (1954).
Properties: Liquid. Fishy amine odor. bp7mm 82-83°. n20D 1.5110. d2020 0.9231. pKa (30°) 10.35. Alkaline reaction. Freely sol in alc. Sol in ether. Practically insol in water.
Boiling point: bp7mm 82-83°
pKa: pKa (30°) 10.35
Index of refraction: n20D 1.5110
Density: d2020 0.9231
Derivative Type: Sulfate dihydrate
CAS Registry Number: 6190-60-9
Trademarks: Wyamine (Wyeth); Mephine
Molecular Formula: (C11H17N)2.H2SO4.2H2O
Molecular Weight: 460.63
Percent Composition: C 57.36%, H 8.75%, N 6.08%, S 6.96%, O 20.84%
Properties: Crystals, mp 215-217° (dec). One gram dissolves in 20 ml water, about 150 ml ethanol (95%). Practically insol in chloroform. pH of aq soln about 6. LD50 (calc as base) intra-abdominally in mice: 89.4 mg/kg (Eckfeld).
Melting point: mp 215-217° (dec)
Toxicity data: LD50 (calc as base) intra-abdominally in mice: 89.4 mg/kg (Eckfeld)
Keywords: a-Adrenergic Agonist.