Mephenytoin
Title: Mephenytoin
CAS Registry Number: 50-12-4
CAS Name: 5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione
Additional Names: 5-ethyl-3-methyl-5-phenylhydantoin; 3-methyl-5,5-phenylethylhydantoin; "methyl hydantoin"; phenylethylmethylhydantoin; 3-ethylnirvanol; methoin
Trademarks: Insulton; Mesontoin; Mesantoin (Sandoz); Phenantoin; Sedantoinal (Sandoz); Gerot-Epilan (Gerot); Sacerno (EGYT)
Molecular Formula: C12H14N2O2
Molecular Weight: 218.25
Percent Composition: C 66.04%, H 6.47%, N 12.84%, O 14.66%
Literature References: Prepn: FR 769667; CH 166004 (both 1934 to Sandoz); CH 179692 (1935 to Sandoz). Pharmacology: I. A. Dzhagatspanyan et al., Pharm. Chem. J. 25, 181 (1991).
Properties: Crystals, mp 136-137°. Insol in water. Forms a water-soluble sodium salt which has an alkaline reaction. LD50 i.p. in mice: 300 mg/kg (Dzhagatspanyan).
Melting point: mp 136-137°
Toxicity data: LD50 i.p. in mice: 300 mg/kg (Dzhagatspanyan)
Therap-Cat: Anticonvulsant.
Keywords: Anticonvulsant.

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