Mersalyl
Title: Mersalyl
CAS Registry Number: 492-18-2
CAS Name: [3-[[2-(Carboxylatomethoxy)benzoyl]amino]-2-methoxypropyl]hydroxymercurate(1-) sodium
Additional Names: o-[[3-(hydroxymercuri)-2-methoxypropyl]carbamoyl]phenoxyacetic acid sodium salt; sodium o-[(3-hydroxymercuri-2-methoxypropyl)carbamoyl]phenoxyacetate; N-(g-hydroxymercuri-b-methoxypropyl)salicylamide-O-acetic acid sodium salt; mercuramide
Trademarks: Salyrgan (Sterling Winthrop)
Molecular Formula: C13H16HgNNaO6
Molecular Weight: 505.85
Percent Composition: C 30.87%, H 3.19%, Hg 39.65%, N 2.77%, Na 4.54%, O 18.98%
Literature References: Prepn: Diels, Beccard, Ber. 39, 4125 (1906); Bockmühl, Schwarz, DE 423031 (1925 to Hoechst); Frdl. 15, 1609. Use as diuretic: F. Brunn, Wien. Klin. Wochenschr. 37, 901 (1924). Toxicity data: E. B. Robbins, K. K. Chen, J. Am. Pharm. Assoc. 40, 249 (1951). Use of acid as physiological sulfhydryl inhibitor: P. Mavier, J. Hanoune, Eur. J. Biochem. 59, 593 (1975).
Properties: Bitter crystals. Somewhat deliquescent. Gradually dec by light. One gram dissolves in about 1 ml water, in about 3 ml ethanol (95%), in 2 ml abs methanol. Practically insol in ether, chloroform. Aq solns are alkaline to litmus. LD50 i.v. in mice, rats: 72.6, 17.7 mg/kg (Robbins, Chen).
Toxicity data: LD50 i.v. in mice, rats: 72.6, 17.7 mg/kg (Robbins, Chen)
 
Derivative Type: Mersalyl Acid
CAS Registry Number: 486-67-9
Molecular Formula: C13H17HgNO6
Molecular Weight: 483.87
Percent Composition: C 32.27%, H 3.54%, Hg 41.46%, N 2.89%, O 19.84%
Properties: Odorless, white, slightly hygroscopic powder. Slightly sol in water, dil mineral acids; sol in solutions of alkali hydroxides.
 
Use: Sulfhydryl specific biochemical probe.
Therap-Cat: Diuretic.
Therap-Cat-Vet: Diuretic.
Keywords: Diuretic; Organomercurials.

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