Methomyl
Title: Methomyl
CAS Registry Number: 16752-77-5
CAS Name: N-[[(Methylamino)carbonyl]oxy]ethanimidothioic acid methyl ester
Additional Names: N-[(methylcarbamoyl)oxy]thioacetimidic acid methyl ester; S-methyl N-[(methylcarbamoyl)oxy]thioacetimidate; methyl O-(methylcarbamoyl)thiolacetohydroxamate
Manufacturers' Codes: Insecticide 1179
Trademarks: Lannate (DuPont); Nudrin (Shell)
Molecular Formula: C5H10N2O2S
Molecular Weight: 162.21
Percent Composition: C 37.02%, H 6.21%, N 17.27%, O 19.73%, S 19.77%
Literature References: Prepn: A. G. Jelinek, ZA 6800093; idem, US 3506698 (1968, 1970 both to du Pont). Metabolism studies: J. Harvey et al., J. Agric. Food Chem. 21, 769, 775, 781 (1973). Crystal structure: Sim, Waite, J. Chem. Soc. B 1971, 752. Acetylcholinesterase activity: Pickering, Pickering, Arch. Toxicol. 27, 292 (1971). Toxicity studies: A. M. Kaplan, H. Sherman, Toxicol. Appl. Pharmacol. 40, 1 (1977).
Properties: Crystals, mp 78-79°. d424 1.2946. Soly at 25° (w/w): water 5.8; methanol 100; ethanol 42; isopropanol 22; acetone 73. LD50 orally in male rats: 17 mg/kg (Kaplan, Sherman).
Melting point: mp 78-79°
Density: d424 1.2946
Toxicity data: LD50 orally in male rats: 17 mg/kg (Kaplan, Sherman)
CAUTION: Potential symptoms of overexposure are eye irritation; blurred vision, miosis; salivation; abdominal cramps, nausea, vomiting; dyspnea; weakness, muscle twitching; liver and kidney damage. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 194.
Use: Insecticide.

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