Methoxychlor
Title: Methoxychlor
CAS Registry Number: 72-43-5
CAS Name: 1,1¢-(2,2,2-Trichloroethylidene)bis[4-methoxybenzene]
Additional Names: 1,1,1-trichloro-2,2-bis(p-methoxyphenyl)ethane; 2,2-di-p-anisyl-1,1,1-trichloroethane; DMDT; methoxy-DDT
Trademarks: Marlate (DuPont)
Molecular Formula: C16H15Cl3O2
Molecular Weight: 345.65
Percent Composition: C 55.60%, H 4.37%, Cl 30.77%, O 9.26%
Literature References: Commercial prepn by the condensation of anisole with chloral in the presence of sulfuric acid: Schneller, Smith, Ind. Eng. Chem. 41, 1027 (1949). Activity: P. Läuger et al., Helv. Chim. Acta 27, 892 (1944). Toxicity study: H. C. Hodge et al., J. Pharmacol. Exp. Ther. 99, 140 (1950). Review of toxicology and human exposure: Toxicological Profile for Methoxychlor (PB2003-100140, 2002) 290 pp.
Properties: Dimorphic crystals, mp 78-78.2° or 86-88°. Practically insol in water. Soluble in alc. The solubilities are approx those of DDT, q.v. LD50 orally in rats: 5.0 g/kg (Hodge).
Melting point: mp 78-78.2° or 86-88°
Toxicity data: LD50 orally in rats: 5.0 g/kg (Hodge)
CAUTION: Potential symptoms of overexposure in exptl animals are fasciculations; trembling, convulsions; kidney and liver damage. Potential occupational carcinogen. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 194. See also Clinical Toxicology of Commercial Products, R. E. Gosselin et al., Eds. (Williams & Wilkins, Baltimore, 5th ed., 1984) Section II, p 284.
Use: Insecticide.
Therap-Cat-Vet: Ectoparasiticide.

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