Methoxypromazine
Title: Methoxypromazine
CAS Registry Number: 61-01-8
CAS Name: 2-Methoxy-N,N-dimethyl-10H-phenothiazine-10-propanamine
Additional Names: 10-(3-dimethylaminopropyl)-2-methoxyphenothiazine; 3-methoxy-10-(3¢-dimethylaminopropyl)phenothiazine; 2-methoxy-10-(3¢-dimethylaminopropyl)phenothiazine; methopromazine
Manufacturers' Codes: RP-4632
Molecular Formula: C18H22N2OS
Molecular Weight: 314.45
Percent Composition: C 68.75%, H 7.05%, N 8.91%, O 5.09%, S 10.20%
Literature References: Prepn: Charpentier et al., Compt. Rend. 235, 59 (1952); R. M. Jacob, J. G. Robert, US 2785160 (1957 to Rhone-Poulenc).
Properties: Crystals, mp 44-48°.
Melting point: mp 44-48°
 
Derivative Type: Maleate
CAS Registry Number: 3403-42-7
Trademarks: Mopazine; Tentone; Vetomazin
Molecular Formula: C18H22N2OS.C4H4O4
Molecular Weight: 430.52
Percent Composition: C 61.38%, H 6.09%, N 6.51%, O 18.58%, S 7.45%
Properties: Crystals, mp 141-145°. Should be protected from light during storage. Soly at 25° (g/100 ml) in water: 0.3; in methanol: 4; in chloroform: 12.5; in dimethylformamide: 100. Very slightly sol in ethanol, benzene. Practically insol in ether. pH of satd aq soln about 5.
Melting point: mp 141-145°
 
Derivative Type: Oxalate
Molecular Formula: C18H22N2OS.C2H2O4
Molecular Weight: 404.48
Percent Composition: C 59.39%, H 5.98%, N 6.93%, O 19.78%, S 7.93%
Properties: Crystals, dec 178-179°.
 
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Phenothiazines.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.

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