Methsuximide
Title: Methsuximide
CAS Registry Number: 77-41-8
CAS Name: 1,3-Dimethyl-3-phenyl-2,5-pyrrolidinedione
Additional Names: N,2-dimethyl-2-phenylsuccinimide; 1,3-dimethyl-3-phenyl-2,5-dioxopyrrolidine; mesuximide
Trademarks: Celontin (Parke-Davis); Petinutin (Parke-Davis)
Molecular Formula: C12H13NO2
Molecular Weight: 203.24
Percent Composition: C 70.92%, H 6.45%, N 6.89%, O 15.74%
Literature References: Prepd by the action of methylamine on a-methyl-a-phenylsuccinic acid: Miller, Long, J. Am. Chem. Soc. 73, 4895 (1951); eidem, US 2643257 (1953 to Parke, Davis). Pharmacology: P. G. Marshall, D. K. Vallance, J. Pharm. Pharmacol. 6, 740 (1954).
Properties: Crystals from dil alc, mp 52-53°. bp0.1 121-122°. Freely sol in methanol, alc. LD50 orally in mice: 0.9 g/kg (Marshall, Vallance).
Melting point: mp 52-53°
Boiling point: bp0.1 121-122°
Toxicity data: LD50 orally in mice: 0.9 g/kg (Marshall, Vallance)
Therap-Cat: Anticonvulsant.
Keywords: Anticonvulsant.

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