Methyl Isothiocyanate
Title: Methyl Isothiocyanate
CAS Registry Number: 556-61-6
CAS Name: Isothiocyanatomethane
Additional Names: methyl mustard oil
Trademarks: Trapex
Molecular Formula: C2H3NS
Molecular Weight: 73.12
Percent Composition: C 32.85%, H 4.14%, N 19.16%, S 43.85%
Line Formula: CH3N=CS
Literature References: Obtained by the action of CS2 on methylamine. Antibacterial activity: P. Klesse, P. Lukoschek, Arzneim.-Forsch. 5, 505 (1955). Toxicity data: E. H. Vernot et al., Toxicol. Appl. Pharmacol. 42, 417 (1977). Headspace determn in wine: N. Gandini, R. Riguzzi, J. Agric. Food Chem. 45, 3092 (1997). Soil degradation study: A. Frick et al., J. Environ. Qual. 27, 1158 (1998).
Properties: Crystals, mp 35-36°. bp 119°. nD37 1.5258. Slightly sol in water; freely sol in alcohol, ether. LD50 in rats, mice (mg/kg): 220, 110 orally; in rabbits (mg/kg): 33 dermally (Vernot). LD50 s.c. in mice: 0.05 g/kg (Klesse, Lukoschek).
Melting point: mp 35-36°
Boiling point: bp 119°
Index of refraction: nD37 1.5258
Toxicity data: LD50 in rats, mice (mg/kg): 220, 110 orally; in rabbits (mg/kg): 33 dermally (Vernot); LD50 s.c. in mice: 0.05 g/kg (Klesse, Lukoschek)
CAUTION: Highly irritating.
Use: Pesticide; soil fumigant.

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