Metiazinic Acid
Title: Metiazinic Acid
CAS Registry Number: 13993-65-2
CAS Name: 10-Methyl-10H-phenothiazine-2-acetic acid
Additional Names: (10-methyl-2-phenothiazinyl)acetic acid; N-methyl-3-phenothiazinylacetic acid; methiazic acid; methiazinic acid; metiazic acid
Manufacturers' Codes: RP-16091
Trademarks: Soridermal (Rh>e-Poulenc); Soripal (Specia)
Molecular Formula: C15H13NO2S
Molecular Weight: 271.33
Percent Composition: C 66.40%, H 4.83%, N 5.16%, O 11.79%, S 11.82%
Literature References: Prepn: FR M4163; Farge et al., NL 6614516; US 3424748 (1966, 1967, 1969 all to Rhône-Poulenc); Messer et al., C.R. Seances Acad. Sci. Ser. C 265 (14), 758 (1967). Series of articles on prepn, pharmacology, toxicology and metabolism: Arzneim.-Forsch. 19, 1193-1221 (1969). Toxicity: L. Joulou et al., ibid. 1198.
Properties: Crystals from benzene, mp 146°. Sol in acetone, ether, chloroform. Forms a water-sol sodium salt. uv max (0.1N NaOH): 253, 305 nm; min 280 nm. LD50 in mice, rats (mg/kg): 800, ~500 orally (Joulou).
Melting point: mp 146°
Absorption maximum: uv max (0.1N NaOH): 253, 305 nm; min 280 nm
Toxicity data: LD50 in mice, rats (mg/kg): 800, ~500 orally (Joulou)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives.

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