Metomidate
Title: Metomidate
CAS Registry Number: 5377-20-8
CAS Name: 1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid methyl ester
Additional Names: 1-(a-methylbenzyl)imidazole-5-carboxylic acid methyl ester; methyl 1-(a-methylbenzyl)imidazole-5-carboxylate; methoxymol; methomidate
Molecular Formula: C13H14N2O2
Molecular Weight: 230.26
Percent Composition: C 67.81%, H 6.13%, N 12.17%, O 13.90%
Literature References: Injectable hypnotic related to etomidate, q.v. Prepn: BE 662474; E. F. Godefroi, C. A. M. van der Eijcken, US 3354173 (1965, 1967 both to Janssen); E. F. Godefroi et al., J. Med. Chem. 8, 220 (1965). Anaesthetic effect of combination with azaperone, q.v.: J. F. F. Callear, J. F. E. Van Gestel, Vet. Rec. 92, 284 (1973); of combination with fentanyl, q.v.: W. Erhardt, J. Small Anim. Pract. 19, 401 (1978); C. J. Green, Lab. Anim. 15, 171 (1981).
 
Derivative Type: Hydrochloride
Manufacturers' Codes: R-7315
Trademarks: Hypnodil (Janssen)
Molecular Formula: C13H14N2O2.HCl
Molecular Weight: 266.72
Percent Composition: C 58.54%, H 5.67%, N 10.50%, O 12.00%, Cl 13.29%
Properties: Crystals from methanol-ether, mp 173-174°. LD50 i.v. in rats: 50 mg/kg (Godefroi).
Melting point: mp 173-174°
Toxicity data: LD50 i.v. in rats: 50 mg/kg (Godefroi)
 
Therap-Cat-Vet: Hypnotic.

Others monographs:
SertindoleNovobiocinTylocrebrinePicoperine
Allopregnane-3α,20α-diolCloxyquinQuizalofop-ethylCymene
Galactaric AcidStavudineDienestrolIodinated Glycerol
ZinostatinDrofenineMagnesonEthyl Cyanoacetate
©2016 DrugLead US FDA&EMEA