Miboplatin
Title: Miboplatin
CAS Registry Number: 103775-75-3
CAS Name: (SP-4-3)-[1,1-Cyclobutanedi(carboxylato-kO)(2-)][(1R,2R)-2-pyrrolidinemethanamine-kN1,kN2]platinum
Additional Names: (-)-cis-[(R)-2-(aminomethyl)pyrrolidine](1,1-cyclobutanedicarboxylato)platinum; (-)-(R)-1,1-cyclobutanedicarboxylato(2-aminomethylpyrrolidine)platinum(II)
Molecular Formula: C11H18N2O4Pt
Molecular Weight: 437.36
Percent Composition: C 30.21%, H 4.15%, N 6.41%, O 14.63%, Pt 44.60%
Literature References: Cytotoxic platinum complex. Prepn: M. Honda et al., EP 176005; eidem, US 4822892 (1986, 1989 both to Chugai); K. Morikawa et al., J. Pharm. Sci. 80, 837 (1991). Comparative antitumor and nephrotoxic activities of isomers: T. Matumoto et al., Br. J. Cancer 64, 41 (1991). Mechanism of action studies: M. Itoh et al., Chem. Pharm. Bull. 37, 2825 (1989); M. Akaboshi et al., Jpn. J. Cancer Res. 85, 106 (1994). Clinical evaluation: K. Tamura et al., Cancer 66, 2059 (1990). Acute toxicity: M. Suzuki et al., Yakuri to Chiryo 20, S743 (1992), C.A. 117, 124096 (1992).
 
Derivative Type: Monohydrate
Manufacturers' Codes: DWA-2114R
Trademarks: Neoplat (Chugai)
Properties: Colorless crystals from water, mp 248-254°. [a]D20 -40.1° (c = 0.4 in water). LD50 in male, female mice, rats (mg/kg): 150, 155, 107, 135 i.v. (Suzuki).
Melting point: mp 248-254°
Optical Rotation: [a]D20 -40.1° (c = 0.4 in water)
Toxicity data: LD50 in male, female mice, rats (mg/kg): 150, 155, 107, 135 i.v. (Suzuki)
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Platinum Complexes.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.

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