Minaprine
Title: Minaprine
CAS Registry Number: 25905-77-5
CAS Name: N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine
Additional Names: 4-[2-[(4-methyl-6-phenyl-3-pyridazinyl)amino]ethyl]morpholine
Molecular Formula: C17H22N4O
Molecular Weight: 298.38
Percent Composition: C 68.43%, H 7.43%, N 18.78%, O 5.36%
Literature References: Prepn: H. Laborit, DE 2229215; idem, US 4169158 (1973, 1979 to Centre Etudes Exper. Clin. Physio-Biologie); C.-G. Wermuth, A. Exinger, Agressologie 13, 285 (1972). Pharmacology: H. Laborit et al., ibid. 291. Metabolism of 14C-minaprine: A. G. Rico et al., J. Pharmacol. 9, 170 (1978). Pharmacokinetics: J. P. Jeanniot et al., ibid. 169. Clinical evaluation: A. Garcia-Maffla, M. H. de Garcia, Pharmatherapeutica 2, 265 (1979). Pharmacological evaluation in depression: K. Bizière et al., Arzneim.-Forsch. 32, 824 (1982). Toxicologic study: A. G. Mazure et al., Agressologie 13, 319 (1972).
Properties: Fine buff-colored needles from isopropanol, mp 122°. Insol in water. Slightly sol in cold ethanol, sol in hot ethanol, chloroform.
Melting point: mp 122°
 
Derivative Type: Dihydrochloride
CAS Registry Number: 25953-17-7
Manufacturers' Codes: Agr-1240; CB-30038
Trademarks: Brantur (Dong-A); Cantor (Sanofi Winthrop)
Molecular Formula: C17H22N4O.2HCl
Molecular Weight: 371.30
Percent Composition: C 54.99%, H 6.52%, N 15.09%, O 4.31%, Cl 19.10%
Properties: Crystals from abs ethanol, mp 182°.
Melting point: mp 182°
 
Therap-Cat: Antidepressant.
Keywords: Antidepressant.

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