Mivacurium Chloride
Title: Mivacurium Chloride
CAS Registry Number: 106861-44-3
CAS Name: (1R,1¢R)-2,2¢-[[(4E)-1,8-Dioxo-4-octene-1,8-diyl]bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]]isoquinolinium dichloride
Additional Names: (R)-1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)isoquinolinium chloride, (E)-4-octenedioate (2:1)
Manufacturers' Codes: BW-B1090U
Trademarks: Mivacron (GSK)
Molecular Formula: C58H80Cl2N2O14
Molecular Weight: 1100.17
Percent Composition: C 63.32%, H 7.33%, Cl 6.45%, N 2.55%, O 20.36%
Literature References: Non-depolarizing neuromuscular blocking agent. Prepn: R. A. Swaringen, Jr. et al., DD 235638; eidem, US 4761418 (1986, 1988 both to Burroughs Wellcome). Clinical pharmacology: H. H. Ali et al., Br. J. Anaesth. 61, 541 (1988); J. J. Savarese et al., Anesthesiology 68, 723 (1988). In vitro metabolism: D. R. Cook et al., Anesth. Analg. 68, 452 (1989). Clinical evaluation in adults: S. Weber et al., ibid. 67, 495 (1988); R. P. From et al., Br. J. Anaesth. 64, 193 (1990); in children: J. K. Alifimoff, N. G. Goudsouzian, ibid. 63, 520 (1989).
Properties: Amorphous solid. [a]20D -62.7° (c = 1.9 in water).
Optical Rotation: [a]20D -62.7° (c = 1.9 in water)
Therap-Cat: Muscle relaxant (skeletal).
Keywords: Muscle Relaxant (Skeletal).

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