Mofebutazone
Title: Mofebutazone
CAS Registry Number: 2210-63-1
CAS Name: 4-Butyl-1-phenyl-3,5-pyrazolidinedione
Additional Names: 4-butyl-1-phenyl-3,5-dioxopyrazolidine; 2-phenyl-3,5-dihydroxy-4-butylpyrazolidine; monophenylbutazone
Trademarks: Arcomonol Tablets; Mobutazon; Mobuzon; Mofesal (Medice); Monazan; Monobutyl; Monorheumetten (Benzon); Reumatox
Molecular Formula: C13H16N2O2
Molecular Weight: 232.28
Percent Composition: C 67.22%, H 6.94%, N 12.06%, O 13.78%
Literature References: Prepn: Büchi et al., Helv. Chim. Acta 36, 75 (1953); GB 839057 (1960 to Comm. Farm. Milanese). Toxicity data: Schoetensack, Arch. Exp. Pathol. Pharmakol. 233, 365 (1958).
Properties: Crystals from ethanol + water, mp 102-103°. uv max (ethanol): 240, 275 nm (E1%1cm 443, 245). LD50 i.v. in mice: 600 mg/kg (Schoetensack).
Melting point: mp 102-103°
Absorption maximum: uv max (ethanol): 240, 275 nm (E1%1cm 443, 245)
Toxicity data: LD50 i.v. in mice: 600 mg/kg (Schoetensack)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Pyrazolones.

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