Motretinide
Title: Motretinide
CAS Registry Number: 56281-36-8
CAS Name: (all E)-N-Ethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenamide
Additional Names: 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraen-1-oic acid ethyl amide
Manufacturers' Codes: Ro-11-1430
Trademarks: Tasmaderm (Roche)
Molecular Formula: C23H31NO2
Molecular Weight: 353.50
Percent Composition: C 78.15%, H 8.84%, N 3.96%, O 9.05%
Literature References: Aromatic analog of retinoic acid, q.v. Prepn: W. Bollag et al., DE 2414619; eidem, US 4215215 (1974, 1980 both to Hoffmann-La Roche). Description of properties: idem, Chemotherapy 21, 236 (1975). 13C-NMR study: G. Englert, Helv. Chim. Acta 58, 2367 (1975). Pharmacology: L. J. Wilkoff et al., Cancer Res. 36, 964 (1976); S. S. Shapiro et al., ibid. 3702. Inhibitory effect on radiation-induced neoplasms: L. Harisiades et al., Nature 274, 486 (1978). Use in treatment of acne: K. Nordin et al., Dermatologica 162, 104 (1981).
Properties: Crystals from ethanol, mp 179-180°.
Melting point: mp 179-180°
Therap-Cat: Antiacne.
Keywords: Antiacne.

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